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Takamitsu Makino Selected Research

Collagen Diseases (Collagen Disease)

5/2020Increased CD27 expression in the skins and sera of patients with systemic sclerosis.
9/2013Serum levels of tenascin-C in collagen diseases.
5/2013Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor β signaling.
9/2011Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients.

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Takamitsu Makino Research Topics

Disease

21Systemic Scleroderma (Systemic Sclerosis)
06/2022 - 08/2009
13Fibrosis (Cirrhosis)
06/2022 - 08/2009
12Neoplasms (Cancer)
01/2022 - 12/2007
6Autoimmune Diseases (Autoimmune Disease)
05/2020 - 04/2012
6Dermatomyositis (Dermatopolymyositis)
10/2015 - 09/2011
5Localized Scleroderma (Morphea)
09/2013 - 05/2008
4Extramammary Paget Disease (Paget Disease, Extramammary)
01/2022 - 05/2019
4Melanoma (Melanoma, Malignant)
09/2021 - 01/2020
4Collagen Diseases (Collagen Disease)
05/2020 - 09/2011
4Systemic Lupus Erythematosus (Libman-Sacks Disease)
08/2017 - 10/2012
3Psoriatic Arthritis
01/2021 - 01/2020
3Psoriasis (Pustulosis Palmaris et Plantaris)
09/2020 - 04/2013
3Rheumatic Diseases (Rheumatism)
10/2015 - 07/2012
2Inflammation (Inflammations)
09/2021 - 09/2014
2Pemphigus (Pemphigus Vulgaris)
01/2021 - 08/2017
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2020 - 12/2007
2Sclerosis
01/2020 - 04/2013
2Erythema
01/2020 - 08/2017
2Cutaneous Fistula
03/2014 - 04/2013
1Lymphatic Metastasis
07/2021
1Neoplasm Metastasis (Metastasis)
07/2021
1Sacroiliitis
01/2021
1Spondylitis
01/2021
1Insect Bites and Stings (Insect Bite)
12/2020
1Behcet Syndrome (Behcet's Syndrome)
11/2020
1Merkel Cell Carcinoma
11/2020
1Hemangiosarcoma (Angiosarcoma)
10/2020
1Alopecia Areata
04/2020
1Alopecia (Baldness)
04/2020
1Experimental Melanoma
01/2020
1Ankylosing Spondylitis
01/2020
1Condylomata Acuminata (Genital Wart)
04/2019
1Erythroplasia
04/2019
1Extrapulmonary Tuberculosis
05/2018
1Infections
05/2018
1Rheumatoid Arthritis
05/2018
1Lymph Node Tuberculosis (Scrofula)
05/2018
1Sepsis (Septicemia)
05/2018

Drug/Important Bio-Agent (IBA)

10CollagenIBA
06/2022 - 02/2012
8MicroRNAs (MicroRNA)IBA
05/2014 - 04/2012
7CytokinesIBA
09/2020 - 08/2009
6DNA (Deoxyribonucleic Acid)IBA
01/2022 - 07/2012
6Biomarkers (Surrogate Marker)IBA
06/2021 - 05/2016
4Bleomycin (Blenoxane)FDA LinkGeneric
06/2022 - 04/2013
4Cell-Free Nucleic AcidsIBA
01/2022 - 09/2020
4Proteins (Proteins, Gene)FDA Link
07/2021 - 07/2011
3Adalimumab (Humira)FDA Link
01/2021 - 05/2018
3Collagen Type I (Type I Collagen)IBA
12/2020 - 04/2012
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2020 - 01/2014
3Adrenal Cortex Hormones (Corticosteroids)IBA
05/2018 - 04/2014
3Silver Sulfadiazine (SSD)FDA LinkGeneric
10/2015 - 09/2013
3ImmunosorbentsIBA
09/2013 - 09/2011
3EnzymesIBA
09/2013 - 09/2011
2alpha2 Subunit Collagen Type IIBA
06/2022 - 09/2015
2Immune Checkpoint InhibitorsIBA
09/2021 - 01/2020
2Interleukin-17 (Interleukin 17)IBA
02/2021 - 04/2012
2AntibodiesIBA
10/2020 - 07/2012
2IntegrinsIBA
09/2015 - 01/2013
2Messenger RNA (mRNA)IBA
01/2014 - 05/2013
2Immunologic Factors (Immunomodulators)IBA
01/2011 - 05/2008
1Small Interfering RNA (siRNA)IBA
06/2022
1Lactic Acid (Lactate)FDA LinkGeneric
09/2021
1Early Growth Response Protein 1IBA
09/2021
1Janus Kinase 2IBA
07/2021
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2021
1ParaffinIBA
02/2021
1Pharmaceutical PreparationsIBA
12/2020
1Transcription Factors (Transcription Factor)IBA
11/2020
1avelumabIBA
11/2020
1Tumor Viral Antigens (Large T Antigen)IBA
11/2020
1Prednisolone (Predate)FDA LinkGeneric
11/2020
1HLA-A*26 antigenIBA
11/2020
1PaxillinIBA
10/2020
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
10/2020
1EndoglinIBA
10/2020
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
10/2020
1SurvivinIBA
10/2020
1Caspase 3 (Caspase-3)IBA
10/2020
1cadherin 5IBA
10/2020
1taxaneIBA
10/2020
1AutoantibodiesIBA
05/2020
1LigandsIBA
05/2020
1squaric acid dibutyl esterIBA
04/2020
1squaric acidIBA
04/2020
1Interleukin-16 (Interleukin 16)IBA
01/2020
1AntigensIBA
01/2020
1OvalbuminIBA
01/2020
1C-Reactive ProteinIBA
01/2020
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2020
1OX40 LigandIBA
01/2020
1Peptides (Polypeptides)IBA
01/2020
1Cyclin-Dependent Kinase 4IBA
05/2019
1Imiquimod (Aldara)FDA LinkGeneric
04/2019
1InterferonsIBA
05/2018
1Interleukin-10 (Interleukin 10)IBA
04/2018

Therapy/Procedure

6Therapeutics
07/2021 - 09/2014
2Immunotherapy
04/2020 - 01/2020
2Skin Transplantation (Skin Grafting)
03/2014 - 04/2013
2Negative-Pressure Wound Therapy
03/2014 - 04/2013
1Drug Therapy (Chemotherapy)
04/2020